Re: [dev] [OT] a "suckless" plasmid

From: Laslo Hunhold <>
Date: Tue, 16 Oct 2018 13:39:36 +0200

On Tue, 16 Oct 2018 09:21:49 +0200
Jens Staal <> wrote:

Dear Jens,

> Just wanted to share a preprint describing the generation of a
> minimalistic plasmid which got 56% size reduction from elimination of
> "useless bloat" DNA code, while actually gaining additional
> functionality (more restriction enzyme cloning sites).
> The preprint paper is not really hypothesis-driven science as such
> and more a description of the generation of a very useful tool, so I
> do not think I will try to make it published "for real".

this looks really interesting! Thanks for sharing this! I like to think
of DNA as a Turing-tape and "optimizing" it (removing old cruft mostly)
is a very adventurous and futuristic approach.

With best regards


Laslo Hunhold <>

Received on Tue Oct 16 2018 - 13:39:36 CEST

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